Investigation of life quality of severe burn patients at rehabilitation stage and analysis of the related influential factors / 中华烧伤杂志

<p><b>OBJECTIVE</b>To investigate the life quality in severe burn patients at rehabilitation stage and analysis of related influential factors.</p><p><b>METHODS</b>Social support rating scale, general quality of life inventory and retrospective investigation were used to evaluate the life quality of 96 severe burn patients (E group, age: over 16 years) at rehabilitation stage,and 96 healthy people were enrolled into our study as control (C group). The relationship between the life quality and sex, age, education background, occupation, post burn time, burn causes, burn depth, total burn surface area, length of hospitalization, medical cost, return to work was respectively analyzed.</p><p><b>RESULTS</b>There was obvious difference in total score of the life quality between two groups (53 +/- 12 in E group vs. 63 +/- 10 in C group, P < 0.01). There were no obvious difference in life quality among patients with different sex, age, education, burn causes, length of hospitalization and medical expenditure( P > 0.05). The score of social function dimension and material function dimension in married patients were higher than that in singles. The life quality had positive correlation with social support score, return to work, post burn time, and occupation. There were negative correlation between deep burn area and life quality.</p><p><b>CONCLUSION</b>The life quality level of severe burn patients at rehabilitation stage is low. Social support, return to work, duration after burn, occupation and deep burn area are correlating factors affecting life quality. Rehabilitation;</p>

Expression of myeloid cell triggering receptor-1 in monocytes at early post-burn stage / 中华烧伤杂志

<p><b>OBJECTIVE</b>To investigate the expression of triggering receptor expressed on myeloid cells (TREM-1) in monocytes of burn patients at early post-burn stage, and its significance.</p><p><b>METHODS</b>The monocytes of 8 healthy volunteers (A group), 29 patients with mild and moderate burn (B group), and 9 patients with severe and very serious burns (C group) were isolated from the blood, and the THEM-1 mRNA and protein expression were determined by semi-quantitative RT-PCR and flow cytometry, respectively. The plasma levels of TNF-alpha, IL-1beta were determined by ELISA method.</p><p><b>RESULTS</b>The value of TREM-1 mRNA expression in A, B and C groups were 0.74 +/- 0.13, 1.24 +/- 0.09, and 1.46 +/-0.07, respectively, and the expression rates on cell surface in the 3 groups were (9 +/- 4)%, (51 +/- 6)%, and (71 +/- 7)%, respectively, and there were significant differences among the three groups (P = 0.000). the plasma levels of TNF-alpha and IL-1beta in B and C groups were obviously higher than that in A group (P = 0.000), and they were positively correlated to TREM-1 expression (rs = 0.68, 0.72, P = 0.000).</p><p><b>CONCLUSION</b>Increased expression of TREM-1 in monocytes of burn patients at early post-burn stage is correlated with the release of inflammatory factors, indicating that TREM-1 might contribute to the onset and development of acute inflammatory response after burns.</p>